IJS: Podcast Series

International Journal of Stroke: Podcast Series

The International Journal of Stroke brings you a series of conversations on stroke

The International Journal of Stroke podcast offers interviews with key figures in the field of stroke research and highlights current topics and issues.

Cost-utility analysis of mechanical thrombectomy between 6 and 24 hours in acute ischemic stroke

Elena Pizzo

Recently, two randomized controlled trials demonstrated the benefit of mechanical thrombectomy performed between 6 and 24 hours in acute ischemic stroke. The current economic evidence is supporting the intervention only within 6 hours, but extended thrombectomy treatment times may result in better long-term outcomes for a larger cohort of patients.

Dr. Elena Pizzo from the Department of Applied Health Research, University College London, is the submitting author of the manuscript ‘Cost-utility analysis of mechanical thrombectomy between 6 and 24 hours in acute ischemic stroke‘

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Cerebral Microbleeds: Beyond the Microscope

Vincent Berezowski

Deciphering the biological mechanisms leading to, or following microbleeds would enable us to address a key question: do microbleeds arise and impact the surrounding parenchyma like a miniature version of intracerebral haemorrhages or do they represent a different kind of injury?

Carmen Lahiff-Jenkins, Managing Editor of the International Journal of Stroke spoke to Dr Vincent Berezowski from the Department of medical Pharmacology, Lille France, submitting author of the review article Cerebral microbleeds: beyond the macroscope whose group analysis supports the need for a convergent effort from clinicians and basic scientists to go beyond the current ‘macro’ view and disclose the cellular and molecular insights of cerebral haemorrhagic microlesions.

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Restart or Stop Antithrombotics Randomised Trial for Oral Anticoagulants

Rustam al-Shahi Salman

We talked results with Prof. Rustam Al-Shahi Salman from the University of Edinburgh.

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Shelia Martins and Raul Nogueira

Endovascular Treatment with Stent-retriever and/or Thromboaspiration vs. Best Medical Therapy in Acute Ischemic Stroke

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Julie Berhardt in Conversation with Dr. Vivian Fu

Prof. Julie Berhardt in conversation with Dr. Vivian Fu who presented the TACAS trial at ESOC

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Helen Rodgers

Prof. Helen Rodgers speaks about the RATULS

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Enchanted Results from the ISC

Craig Anderson

Carmen Lahiff-Jenkins spoke to Craig Anderson, after a 7 year trial what does ENCHANTED results released today at the International Stroke Conference in Hawaii.

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Excess Stroke Incidence in Young Aboriginal People in South Australia: Pooled Results From Two Population-Based Studies

Anna Balabanski

Retrospective data indicate increased stroke incidence in Aboriginal/Torres Strait Islander (Indigenous) Australians, possibly with poorer outcomes.
Carmen Lahiff-Jenkins, Managing Editor of the International Journal of Stroke and spoke to Dr Anna Balabanski from the Alfred Hospital and Monash University, corresponding author for the article Excess stroke incidence in young Aboriginal people in South Australia: pooled results from two population-based studies, this article  presents the first prospective population-based stroke incidence study in Indigenous Australians.

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Post-Stroke Infections and Preventive Antibiotics in Stroke: Update of Clinical Evidence

Jan-Dirk Vermeij

Infection is a common complication after stroke, affecting between 15% and 30% of patients. The predictors for post-stroke infection can be divided into three categories: clinical factors, anatomical (stroke related) factors and immunological factors. The relation between the occurrence of a post-stroke infection and functional outcome remained subject of debate, but it seems likely that the occurrence of these infections have a causal relation with poor functional outcome and mortality. It has now become clear that, despite the finding that overall infections are reduced, preventive antibiotic therapy in the acute phase of stroke does neither improve functional outcome, nor decrease mortality rates.

Carmen Lahiff-Jenkins, Managing Editor of the International Journal of Stroke spoke to Dr Jan-Dirk Vermeij from the Department of Neurology, Academic Medical Center, Amsterdam and submitting author of the paper Post-stroke infections and preventive antibiotics in stroke: update of clinical evidence. Dr Jan-Dirk Vermeij from the Department of Neurology, Academic Medical Center, Amsterdam is the submitting author of the manuscript Post-stroke infections and preventive antibiotics in stroke: update of clinical evidence that was published in the International journal of stroke.

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Systematic Review of Organizational Models for Intra-Arterial Treatment of Acute Ischemic Stroke

Alfonso Ciccone

Dr Alfonso Ciccone director of the department of neuroscience at the hospital Mantova in Italy explained how they conducted research to identify models for delivery of intra-arterial treatment and to compare process performance and clinical and radiological outcomes effectiveness of the different models.

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Trial Results from VERSE

Erin Godeke

Carmen Lahiff-Jenkins, Managing Editor of the International Journal of Stroke spoke to the fabulous Erin Godeke about the VERSE trial and results JUST announced at WSC in REAL TIME!

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Conversation with Maynak Goyal SSA/Smartstrokes

Stephen Davis

In this podcast you will be privy to an important and insightful conversation on the big questions in endovascular thrombectomy between Professor Stephen Davis Director of the Melbourne Brain Centre RMH and the University of Melbourne and Maynak Goyal interventional radiologist University of Calgary.

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Avril Drummond in Conversation with Richard Lindley

Avril Drummond and Richard Lindley

In this podcast you will be privy to a fascinating conversation by Professor of Geriatric Medicine Richard Lindley from The George Institute, Australia and Professor of Health Care Research Avril Drummond at the University of Nottingham, in the UK.

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Sedentary Behaviour After Stroke: A New Target for Therapeutic Intervention

Sarah Morton

Over the last 10 years evidence has emerged that too much sedentary time (e.g. time spent sitting down) has adverse effects on health, including an increased risk of cardiovascular disease incidence and mortality. A considerable amount of media attention has been given to the topic. The current UK activity guidelines recommend that all adults should minimise the amount of time spent being sedentary for extended periods. How best to minimise sedentary behaviour is a focus of ongoing research.

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Computed Tomographic Angiography in Stroke and High-Risk Transient Ischemic Attack: Do not leave the emergency department without it!

Brett R Graham

Stroke is a major cause of morbidity and mortality worldwide, and effective treatment requires rapid diagnosis and recognition of relevant vascular lesions.

Dr Brett Graham from the Calgary Stroke Program in Saskatchewan is the lead author of the review Computed tomographic angiography in stroke and high risk TIA: Don’t leave the ED without it! In this review the authors discuss the usefulness and versatility of computed tomography angiography in the setting of stroke, highlighting the use of computed tomography angiography in decision making in transient ischemic attacks, acute disabling ischemic stroke, and hemorrhagic stroke.

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Tobacco Control for The World Health Organisation

Lubna Bhatti

Tobacco Control for The World Health Organisation

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Refining the Ischaemic Penumbra with Topography

Thanh Phan

It has been forty years since the ischaemic penumbra was first conceptualised through work on animal models. The topography of penumbra has been portrayed as an infarcted core surrounded by penumbral tissue and an extreme rim of oligaemic tissue. In the paper‘Refining the Ischaemic Penumbra with Topography’ first Author Thanh Phan et al reviewed the understanding of the topography of the ischaemic penumbra from the initial experimental animal models to current developments with neuroimaging which have helped to further define the temporal and spatial evolution of the penumbra and refine our knowledge.

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Rationale, Design, and Protocol of a Randomized Controlled Trial of the Safety and Efficacy of Dabigatran Etexilate Versus Dose-Adjusted Warfarin in Patients with Cerebral Venous Thrombosis

Jose Ferro

To prevent recurrent venous thrombotic events after acute cerebral venous or dural sinus thrombosis, guidelines recommend long-term oral anticoagulation with vitamin K antagonists. Non-vitamin K oral anticoagulant experience in cerebral venous or dural sinus thrombosis is limited to case reports and series.

Professor Jose Ferro from University of Lisbon – Neurology Hospital Santa Maria, Lisbon, Portugal.

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Conversation with Janice Eng SSA/Smartstrokes

Janice Eng

In this podcast you will be privy to this important interview with Professor Janice Eng from GF Strong Rehab Centre and University of British Columbia, Canada

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Breaking Up Sitting Time After Stroke (Bust-Stroke)

Coralie English

People with stroke sit for long periods each day, which may compromise blood glucose control and increase risk of recurrent stroke. Studies in other populations have found regular activity breaks have a significant acute positive effect on glucose metabolism. We examined the effects of breaking up uninterrupted sitting with short, regular activity breaks in people with stroke on post-prandial plasma glucose and insulin.

The International Journal of Stroke first published the BUST-Stroke: Breaking Up Sitting Time after Stroke protocol paper in 2016, and are very pleased to publish the results and a further paper on frequent, short bouts of light-intensity exercises while standing and the decreases of systolic blood pressure.

Carmen Lahiff-Jenkins, Managing Editor of the International Journal of Stroke had the opportunity to speak to Dr Coralie English from the John Hunter Hospital, Newcastle Australia, who is the lead investigator for BUST-Stroke.

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From the World Obesity Society

Johanna Ralston

Johanna Ralston, Director of the World Obesity Society, speaks about the impact of obesity on stroke.

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Fienburg award recipient

Johanna Wardlaw

Carmen Lahiff-Jenkins, managing editor of the IJS chatted to Fienburg award recipient, Johanna Wardlaw

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Defuse 3

Michael Mlynash

Interview on the ground with Michael Mlynash

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Cerebral Amyloid Angiopathy Associated with Inflammation

Hugh Markus

This podcast interview is based on the article Cerebral amyloid angiopathy associated with inflammation (CAA-I): a systematic review of clinical and imaging features and outcome, by Andrej Corovic, Siobhan Kelly and Hugh Markus.

Cerebral amyloid angiopathy associated with inflammation (CAA-I) is an increasingly recognised condition, characterised by an inflammatory response to the vascular deposits of β-amyloid within the brain that are the hallmark of cerebral amyloid angiopathy (CAA).

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Infarct Location is Associated with Quality of Life After Mild Ischemic Stroke

Chen Lin

In patients with mild ischemic stroke, small but eloquent infarcts may have devastating effects, particularly on health-related quality of life. Carmen Lahiff-Jenkins, Managing Editor of the International Journal of Stroke spoke to Dr Chen Lin from Northwestern University Feinberg School of Medicine, Chicago Illinois in the US, who was lead author for the article ‘Infarct location is associated with quality of life after mild ischemic stroke’, recently published in IJS.

This study looks at the association between acute infarct location and 3-month health- related quality of life in patients with mild ischemic stroke.

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The Brain Health Index: Towards A Combined Measure of Neurovascular and Neurodegenerative Structural Brain Injury

David Dickie

A structural MRI measure of combined neurovascular and neurodegenerative burden may be useful as these features often coexist in older people, stroke and dementia. Carmen Lahiff-Jenkins, Managing Editor of the International Journal of Stroke spoke to Dr David Dickie from the University of Glasgow lead author of ‘The Brain Health Index: Towards a combined measure of neurovascular and neurodegenerative structural brain injury’. The author aimed to develop a new automated approach for quantifying visible brain injury from small vessel disease and brain atrophy in a single measure, the Brain Health Index.

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Guidelines for Treatment of Susac Syndrome (SUS)

Robert Rennebohm

Susac syndrome (SuS) affects the brain, retina, and inner ear. And whose treatment is particularly challenging. Adding to the challenge is the absence of objective biomarkers of disease activity and the great variability in presentation, timing and extent of peak severity, duration of peak severity, and natural disease course.

Dr Robert Rennebohm from The Susac Syndrome Consultation Service at the Cleveland Clinic, based in Cleveland, Ohio in the USA gave us an expert insight into this little-known syndrome.

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Shared decision making after severe stroke- how can we improve patient and family involvement in treatment decisions?

Akila Visvanathan

You have probably heard someone say, at least once in your lifetime that they would rather die than attempt to live after a severe stroke, which could leave them permanently disabled. But when survivors of severe stroke and serious disability are asked that question after the event they inevitably say they are happy to have survived! Many routine treatments provided after an acute stroke (e.g. feeding via a tube) increase survival, but with disability. So we know that clinicians need to support patients and families in making informed decisions about the use of these treatments, and this is a process termed ‘shared decision-making.

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The PRE-hospital Stroke Treatment Organization (PRESTO)

James Grotta

The PRE-hospital Stroke Treatment Organization (PRESTO) was formed in 2016 as an international consortium of medical practitioners involved in pre-hospital treatment of patients with acute stroke. PRESTO’s mission is to improve stroke outcomes by supporting research and advocacy for pre- hospital stroke treatment in Mobile Stroke Units. The plan is that PRESTO will provide a platform to enhance collaborative research across the spectrum of acute stroke management in the pre-hospital setting. PRESTO will also facilitate the appropriate proliferation and distribution of MSUs by providing a forum for professional communication, resource for public education, and stimulus for government, industry, and philanthropic support.  PRESTO is not-for-profit, with membership open to anyone involved (or hoping to become involved) in pre-hospital stroke care. PRESTO has a Steering Committee comprised of members from Europe, U.S., Canada, Australia, and other regions having a MSU in operation. PRESTO convenes satellite meetings for membership at the ISC and ESOC each year to address the PRESTO mission.

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